Ultrastructural changes of liver parenchyma following digitonin-pulse perfusion of rat liver
نویسندگان
چکیده
منابع مشابه
Digitonin perfusion of rat liver
Perfusing a rat liver with digitonin in the concentration range 2-20mg/ml results in complete decolorization of the organ within 45-250s. Decolorization progresses with time in the direction of flow, and it is therefore possible, by collecting the eluate, to obtain material from specific intracellular compartments of hepatocytes in different zones in the microcirculatory unit of the liver. The ...
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Purpose: This study was designed to determine the histopathologic changes of rat liver while all of the experiments were exposed to formaldehyde for 18 weeks. Materials and Methods: This study was performed on 28, 6-7 week postantal allbino wistar rats. The rats were divided into 3 case groups (E1: 4h/d, 4d/w; E2: 2h/d, 4d/w; E3: 2h/d, 2d/w) and 1 control group. The liver specimens were sectio...
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A previously described digitonin-perfusion technique [Quistorff, Grunnet & Cornell (1985) Biochem. J. 226, 289-297], by which intracellular material of rat liver could be liberated, has been refined, now allowing release of cytosol of high purity from both periportal and perivenous parts of the same liver. The cytosolic fractions are obtained by perfusing the liver for short intervals (10-20 s)...
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The potential to cause tissue damage by metal ions is the matter of widespread investigation. Titanium salts are widely used in industry for ceramic painting, in pharmacy for tablet coating and making chemical sunscreens and in medicine as photo catalysts with bactericidal activity. This may address the idea that the exposure to these salts could play a role in metabolic disorders. In this stud...
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ژورنال
عنوان ژورنال: Cell and Tissue Research
سال: 1990
ISSN: 0302-766X,1432-0878
DOI: 10.1007/bf00313520